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Description

Evidence from studies in vivo suggests that androgen deficiency is closely associated with decreases in ATP synthesis and the activity of complexes I and III in the hippocampus and substantia nigra of castrated male rats (122)

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Similarly, cisplatin, a chemotherapy chemical, caused toxic complications of autophagy and cell death in mouse renal tubular epithelial EpiCM-a cells through ERK1/2 activation, whereas aristolochic acid I attenuated cell apoptosis through pERK1/2-mediated autophagy activation in rat RTCs (NRK-52E) 41

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