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Regarding the patients without a history of gastrectomy, topical antifungal therapy (nystatin suspension 4 mL of 100,000 units/mL, 3 times/day, topical) was administered to 6 patients, CMC-based artificial saliva and clonazepam (0.5 - 1.0 mg/day, topical and/or p.o.) to 4 patients, and CMC-based artificial saliva only to 1 patient

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Moreover, although preclinical studies have yielded promising results, large-scale, double-blinded clinical trials remain necessary to verify the therapeutic efficacy and feasibility of these approaches in DN patients