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The presence of tumor stem cells is directly correlated with chemotherapy resistance in HGSOC, and these cells can evade drug effects through multiple mechanisms ( In our comprehensive exploration of HGSOC drug resistance mechanisms, we identified a complex and diverse biological foundation involving abnormalities in multiple cellular signaling pathways and alterations in the tumor microenvironment

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doi: 10.1021/acscentsci.9b01063

To examine whether the extra insertion of the EHL domain of LotA 7290 resembled any known structures, we performed a structural similarity analysis