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However, some electrons may react directly with O 2 to form O 2 , and spontaneously disproportionate to O 2 and H 2 O 2 with manganese superoxide dismutase (MnSOD) [32]

Mutations in critical transporter and enzyme genes disrupt these steps and underlie a spectrum of neurological disorders collectively termed riboflavin-responsive neurometabolic diseases. A representative example is riboflavin transporter deficiency (RTD), caused by loss-of-function mutations in SLC52A2 and SLC52A3 , which encode the riboflavin transporters RFVT2 and RFVT3, respectively

Fifth, on chromosome 20, we identified an intronic variant in the GGT7 gene, which is linked to chronic kidney disease (CKD), suggesting a potential association between glaucoma and CKD 67