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These circulating spheres of membrane range in size from 0.11m and carry surface signature molecules of their cell of origin, varying with specific disease conditions including various cardiovascular diseases (Boulanger et al., 2006

Catalyzed hairpin assembly [CHA] and HCR are enzyme-free amplification methods that have been used more often because of their high amplification efficiency, minimal background signal, and isothermal reaction conditions

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Investigation of the intestinal flora of patients with AMD using metagenomic sequencing revealed that the AMD group exhibited a notably diminished presence of Firmicutes and an elevated prevalence of Proteobacteria and Bacteroidetes compared with the control group