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Swine IV (SIV) infection resulted in NLRP3 inflammasome activation, leading to IL-1 production in primary porcine alveolar macrophages (PAMs) [122]

Biosci Biotechnol Biochem 61(12):19771980 Van Der Werf P, Orlowski M, Meister A (1971) Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the -glutamyl cycle

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For example, Ulixertinib, an established ERK2 inhibitor, has been modified to identify new structures with similar binding properties, showing promising pharmacodynamic and pharmacokinetic profiles in preclinical studies (Pathania et al., 2022[102])