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Elevated estrogen can further increase histamine by stimulating mast cells to release histamine and decreasing diamine oxidase (DAO), the enzyme responsible for breaking down ingested histamine

Yin X, Xu R, Song J, et al

The genome editing methods are based on the manipulations of the nucleotide sequences in a strictly specified location and with a minimum number of off-target changes in the genome, and are supposed to be environmentally friendly