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Currently, several studies have indicated that early improvement in the hypoxic state of the infarct site can benefit ischemia stroke treatment [129, 130]

doi:10.1016/j.neubiorev.2016.08.014

An overexpression study has shown that T185S variation destabilizes TMEM106B protein [61], but this is not supported by other cell culture and mouse studies [135, 150, 152, 153]