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A., Sahay

Knockdown efficiencies of 50% could be achieved in this 3D culture system (Fig S5B), which for both effectors led to a significant impairment in the formation of duct-like ring structures by RGKO acini (Fig 5C)

Furthermore, in DHEA-induced female mice exhibited upregulation of the metabolite agmatine from Bacteroides vulgatus was upregulated, which activates the farnesoid X receptor (FXR) pathway to inhibit glucagon-like peptide-1 (GLP-1) secretion in intestinal epithelial L cells

Microbiota not only refers to bacteria, but encompasses all the microorganisms of the body, including archaea, fungi, protozoans, bacteria, and viruses (Lederberg and McCray, 2001

Existing targeted strategies show promise but require overcoming the aforementioned challenges