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Toxicity of DCVC to kidney cells has been associated with (1) covalent modification of macromolecules, (2) depletion of nonprotein thiols (presumably mostly GSH), (3) lipid peroxidation (Beuter et al., 1989, Chen et al., 1990, Groves et al., 1991), and (4) carbonylation of susceptible proteins (Fan et al., 2014)

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The upregulation of Gln metabolism is a hallmark of PCa and several other types of tumors, including glioblastoma (GBM) [2], colorectal [3], pancreatic [4], lung [5], and prostate cancer (PCa) [6]

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