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To summarize, the miR-7/NLRP3 pathway plays a vital role in the neuroinflammatory mechanisms linked to PD ( 5.5 miR-let-7a In the mouse model of PD induced by -Syn, miR-let-7a expression was found to be reduced, while STAT3 exhibited concurrent activation in SNpc

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Since ABCB7 shares 42% and 29% sequence identity, respectively, with these transporters, we hypothesized that it might similarly mediate the active transport of porphyrins from the mitochondrial matrix to the intermembrane space (Supplementary Fig 1)

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Nov 2022;32(6):812-816

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