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& ORiordan, J

Consequently, the level of protection of the skin can be reduced and, often, be less than desired

Interestingly, Met is a double-edged sword in health and disease

By exploiting tumor-associated enzymes, such as dehydrogenases, hydrolases, and cathepsins, PROTAC activity can be gated with enhanced tissue selectivity and minimized off-target effects [159, 160]