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Studies utilizing radioactive proline incorporation assays have confirmed that GHK-Cu increases both collagen synthesis rates and the proportion of newly synthesized collagen that successfully incorporates into extracellular matrix structures

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Phytomedicine 20, 11721179

The transcriptional regulator STAT3 elicits PINK1-dependent mitophagy, which eliminates dysfunctional mitochondria, reverses the collapse of the mitochondrial membrane potential, and represses mtROS release and NLRP3 inflammasomes, whilst STAT3 downregulation protects against osteoclastogenesis (156)