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Pigment epithelium-derived factor inhibits oxidative stress-induced cell death by activation of extracellular signal-regulated kinases in cultured retinal pigment epithelial cells

However, a 2025 review noted only 3 RCTs, calling for larger trials (Nguyen et al., 2025)

However, univariate GLM with age as a covariate revealed other neurochemical abnormalities in the pgACC, notably in concentration of lactate (F = 4.684, p = 0.013) (Fig