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P/A, Pro residues of the TrM were exchanged with Ala residues, TrM , the TrM was replaced by alanine residues (Prochaska et al., 2018)

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Non-motor function is also affected by changes in circadian rhythm and gut function preceding motor impairments, suggesting an early impact of the syn transgene in areas outside the nigrostriatal system, akin to the prodromal phase of human PD [54, 55]