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However, the consequences of DNA damage- even at low levels - on IFN I signalling and inflammation could be potentiated if concurrent damage to the nuclear envelope facilitates DNA release from the nucleus and subsequent sensing by of cytosolic DNA or when damage to the cell membrane facilitates the release of DNA together with other DAMPs and thus, the formation of immune complexes

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Activation of Toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice

10.1016/j.molcel.2018.10.042 Mol

J Biol Chem 242: 54905494