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found that in a rat rotator cuff tear model, a self-healing hydrogel releasing curcumin and Mg 2+ synergistically promoted tendon-to-bone healing by reducing inflammation and oxidative stress while enhancing stem cell chondrogenesis, fibrocartilage formation, and biomechanical strength ( in vitro human tenocyte model, tannic acid-coated curcumin-loaded acetalated dextran nanoparticles (TA-Cur-AcDEX NPs) developed via microfluidics showed strong anti-inflammatory and anti-fibrotic effects, significantly downregulating NF-B, TGF-, and MMP-3/9 expression while enhancing nanoparticle stability, uptake, and biocompatibility (Molinaro et al., 2023)

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A mutation in the mitochondrial protein UQCRB promotes angiogenesis through the generation of mitochondrial reactive oxygen species