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We found that pharmacological MT1 and MT2 agonism failed to replicate the effects of melatonin in suppressing IL-5 production ( Figures 3B, D ) or IL-13 production ( Figures 3C, E )

Metformin, as an AMPK activator, inhibits the AMPK-mTOR-STAT3 axis, reduces mtDNA mutations and ROS generation in lupus models, and enhances mitophagy

The concentration of the remaining extracellular peroxides of MM cultures of strains 972 (WT), SG4 ( tpx1 ), EP198 ( ctt1 ), and SG267 ( tpx1 ctt1 ), treated with 0.1 or 0.5 mM H 2 O 2 , was determined at the times indicated with a colorimetric reaction (see Methods)

The ideal pharmacological agent for UF should be effective and affordable, with a short treatment duration and minimal adverse effects

All patient primary diagnosis slides were reviewed by a single pathologist (E.E.) to confirm primary epithelial ovarian cancer diagnosis