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The increase of intracellular ROS is believed to correlate with the activation of nuclear factor (NF)-kappa B, a transcription activator linked to the elaboration of several cytokines (Figure 6)

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cytoplasm), malic enzyme-3 (ME3

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Protein misfolding and failure of clearance systems, including the autophagy-lysosome and ubiquitin-proteasome pathways, further compromise the cellular environment and lead to toxic intracellular accumulations [31, 32]