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Effects of L-citrulline supplementation and aerobic training on vascular function in individuals with obesity across the lifespan

2) Evaluating the quality of health care services received by people with RA and conducting pharmaco-epidemiology studies, using BC administrative health data

3.3 Immune system enhancement The natural substances can act as immune checkpoint and co-inhibitory modulators, some polyphenols decrease the expression of tissue-and tumoural PD-L1 or of CTLA-4 on T cells giving a mechanistic reasoning to combination with nutritional support in patients treated with check point inhibitors, eventually reversing acquired resistance to treatment or decreasing the effective dose for drug administration (193)

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