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10.1016/j.dsx.2023.102934 166 ShiH.YuanX.YangX.HuangR.FanW.LiuG

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In 1969, the anticancer effect of CP was evaluated in the sarcoma mouse model (Rosenberg et al., 1969), and by 1971, CP had entered phase I clinical trials and was finally approved by the US Food and Drug Administration for the management of cancers in 1978 ( It is currently well established that CP mediates its tumoricidal effects through binding to DNA, causing formation of intra- and interstrand cross-links

In the Americas, adult HF prevalence ranges from 1.9 to 2.6%, with higher rates in elderly populations, and projections suggest it could reach 8.5% in individuals aged 6570 years (Bozkurt et al., 2023)