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After acclimatization for 1 week at 5 weeks of age, KKay mice were placed on a high-fat diet (HFD, 60% energy from fat, 20% protein, 20% carbohydrate

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MSM pre-treatment before endurance exercise, which is a known trigger for ROS production, can attenuate protein oxidation, lipid peroxidation, creatine kinase, oxidized glutathione, and uric acid, and also increase total antioxidant capacity (5)

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