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The efficacy of glutamine supplementation in cancer patients is frequently questioned due to confusion and controversial results

Tripolino C, Ciaffi J, Ruscitti P, Giacomelli R, Meliconi R, Ursini F (2021) Hyperuricemia in psoriatic arthritis: epidemiology, pathophysiology, and clinical implications

For microglia, after spinal cord injury (SCI), the concentration of lactate increases, triggering H4K12 lactylation, which is involved in the repair and functional recovery of spinal cord injury [137]

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This may be due to the lower flexibility of the alkyl-connected thalidomide-based PROTAC, which may not favor the formation of a stable ternary complex essential for the transfer of ubiquitin units from the E3 ligase to the target