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Finally, low glutamine in the core region of solid tumors led to histone hypermethylation due to decreased -ketoglutarate level, resulting in cell dedifferentiation and therapeutic resistance in melanoma cells [64]

Understanding the Cellular Energy Coenzyme Image Source: Nature Nicotinamide adenine dinucleotide (NAD) exists as a vital coenzyme in every living cell

Participants either followed an exclusion diet, defined as gluten and casein free regimen adopted independently by families before enrolment, or an unrestricted die, an important source of baseline heterogeneity, as dietary patterns were not experimentally assigned

Concurrently, Cu + triggers cuproptosis by promoting DLAT oligomerization and downregulating Fe-S cluster proteins, demonstrating high performance in tumor suppression (Meng et al., 2025)

Spermidine pretreatment enhances heat tolerance in rice seedlings through modulating antioxidative and glyoxalase systems