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Depletion of a discrete nuclear glutathione pool by oxidative stress, but not by buthionine sulfoximine

Ferroptosis is regulated mainly by the GSH/GPX4 pathway 23

Vidal-Alaball J, Butler CC, Cannings-John R, Goringe A, Hood K, McCaddon A, McDowell I, Papaioannou A

The middle section highlights future precision targeting strategies, such as phage therapy for the precise clearance of pathogens like Klebsiella, engineered bacteria for the synthetic delivery of therapeutic molecules (e.g., IL-10), and microbial enzyme inhibitors targeting pathways like CutC/D to reduce harmful metabolites such as TMA/TMAO

El glutatin, conocido como el antioxidante maestro, junto con la L-cistena, acta neutralizando los radicales libres que daan las clulas