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The compound's unique -peptide bond between glutamate and cysteine renders it resistant to degradation by common peptidases, allowing intracellular accumulation to protective concentrations

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Several authors have shown that high doses of vitamin E can also interfere with drug metabolism (Galli et al., 2017)

10.1615/JEnvironPatholToxicolOncol.v30.i3.70 54

While all the kynurenines are stable in plasma for at least one year when stored at 80C (145), 3-hydroxykynurenine (HK) and to a larger extent 3-hydroxyanthranilic acid (HAA) decrease significantly in chilled EDTA and heparin blood (147), in serum and plasma at room temperature and in serum at 25C (89)