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doi: 10.3109/10715761003667554

Superoxide dismutase I

While targeted therapies have made significant strides in GBM management, their clinical efficacy remains inconsistent due to tumor heterogeneity and acquired resistance

As with any treatment, the potential benefits must be weighed against the potential risks

Studies show core biological changes, including reduced NK cell function, activation of the NLRP3 inflammasome, altered interferon and cytokine signaling, and evidence of mitochondrial and metabolic dysfunction (lactate/pyruvate, haptoglobin)