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In this regard, the European Medicines Agency (EMA) has issued a relevant decree requiring that the production of clinically applied MSCs must comply with GMP to ensure the repeatability, effectiveness and safety of therapeutic products [107]

The combination activates two separate points in the GH regulatory axis simultaneously, which is pharmacologically distinct from activating either point in isolation

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Structural and functional changes in the atria affect these physiological processes and contribute to the development of ACM (Figure 2)

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