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Data availability Datasets generated for this study including murine scRNA-seq data and the human cell line and slice culture scRNA-seq data are deposited in the Gene Expression Omnibus ( The source data of this paper are collected in the following database record: biostudies:S-SCDT-10_1038-S44318-024-00176-4

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An overall agreement on the beneficial effects of cocoa flavanols on cardiovascular function has been proclaimed since the pioneer studies from two decades ago [169,170,171,172,173,174,175], through the first human trials [176,177,178] and first meta-analysis of controlled trials [179,180,181], up to the recent reviews [182,183,184,185,186,187,188]

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Composed of glutamic acid, cysteine and glycine, glutathione plays a central role in numerous biochemical processes and has become one of the most extensively studied endogenous compounds in molecular biology and cellular research

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