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This is a scenario which overstresses the remaining beta cells, which are still capable of providing insulin in the diabetic metabolic state and thus gives rise also to more misfolded proinsulin (Lenzen 2017)

doi: 10.1016/j.parkreldis.2016.08.019 252 LiuJLvXYeTZhaoMChenZZhangYet al

[8] [12] [30] Transaldolase Transaldolase was discovered in 1953 by Horecker and Smyrniotis in brewers yeast, identified as Saccharomyces cerevisiae

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102 This is done by reducing IL-6, inhibiting B cell, T cell, and Natural Killer (NK) cell activation, as well as decreasing M1 and enhancing M2 activation