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Specifically, for the CY 2025 performance period/2027 MIPS payment year, the APP Plus quality measure set will now include the measures in the existing APP quality measure set that are also Universal Foundation measures as described in Table 68 and the following quality measure from the Universal Foundation of measures: The Breast Cancer Screening (Quality ID #112) measure

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Key handling errors that can cause problems include: Shaking the vial vigorously during reconstitution, which denatures the peptide Using sterile water instead of bacteriostatic water, which lacks preservatives and allows bacterial growth Storing reconstituted peptide at room temperature instead of refrigerated Leaving the vial exposed to light, which degrades photosensitive amino acids Using reconstituted peptide beyond its stability window, typically 3-4 weeks Properly handled AOD 9604 should be clear and colorless in solution

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