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Activated platelets can amplify the coagulation response and trigger thrombin-dependent intrahepatic fibrin(ogen) deposition

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Hepatic Vegf levels and expression of its receptors Vegfr1, 2, and 3 were increased after APAP overdose in mice and rats.57, 58, 59 Whereas treatment with VEGFR inhibitor in mice impaired hepatocyte proliferation, 57 the administration of human recombinant VEGF increased hepatocyte regeneration after APAP overdose in mice, without altering initial hepatotoxicity