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In addition, increased p53 expression inhibits the expression of the system xc SLC7A11, resulting in reduced uptake of cystine, decreased GSH peroxidase activity, reduced cell antioxidant capacity, and increased sensitivity of cells to ferroptosis (Kang et al., 2019)

340 Binding immune complexes (ICs) to FcRIIa activates neutrophils, triggering cellular responses such as degranulation, cytoskeletal reorganization, production of ROS and inflammatory mediators, and the generation of NETs

Ferroptosis in tumor therapy Targeted cell death is a common approach in tumor therapy [143]

Glutathione work primarily by inhibiting the enzyme tyrosinase, which is responsible for melanin synthesis in the skin

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of alzheimer amyloidosis