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10.16252/j.cnki.issn1004-0501-2009.05.005 398 ZhouY

In the ER, unfolded or misfolded proteins are detected and retained until they are properly folded or degraded

(PubMed) Khalili M, Eghtesadi S, Mirshafiey A, et al

However, when it is disturbed, neurodegeneration can result (Parakh et al., 2013

Interestingly, this region has very high LD and contains several gene families with known metal tolerance roles and gene ontologies that support metal transport mechanisms or metal-induced stress responses