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The preparation should be applied to the skin externally, massaged or introduced using physical techniques that support the transport of active substances through the epidermis

The higher upfront cost translates to better bioavailability and faster results

Oxidative medicine and cellular longevity (2020) Guo, S., Dipietro, L.A.: Factors affecting wound healing

When you understand that retinol temporarily increases skin sensitivity, the logic behind pairing it with hydrating, barrier-supporting ingredients makes perfect sense