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[DOI] [PubMed] [Google Scholar] 50.Reddy M.K., Alexander-Lindo R.L., Nair M.G

The western blot results indicated that OGD and erastin caused a decrease in SLC7A11 and GPX4 protein levels, which were rescued with the addition of Fer-1 (Fig

Glutathione is often called the body's master antioxidant it plays a central role in cellular detoxification, immune support, and protecting the body from oxidative stress

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However, studies only points to the key role of BH4 in protecting cells when GPX4 is inhibited, and its influence on lipid peroxidation is unrelated to its cofactors, but the specific mechanism remains unclear ( SLC7A11 (xCT) With the deepening of ferroptosis research, studies have strengthened the strategy of using the Cystine/Glutamate reverse transporter SLC7A11 (xCT) pathway to regulate ferroptosis, the principle of which is also based on the antioxidant axis system x c - -GSH-GPX4, but the focus falls on the key precursor system of the system x c - ( c - is actually a sodium-independent antiporter, consisting of the heavy chain subunit solute carrier family 3 member 2 (SLC3A2) and the light chain subunit SLC7A11 ( c - ( Figure 1B )