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Ipamorelin's fat-loss case rests on the well-established fact that GH elevation promotes lipolysis, but the number of steps between ipamorelin injection and actual fat oxidation is longer, and no dedicated human fat-loss trial for ipamorelin exists in the peer-reviewed literature

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Ipamorelin is also listed under WADA's S2 category (growth hormone secretagogues and releasing factors) on the Prohibited List, banned both in and out of competition for athletes subject to anti-doping rules

Ipamorelin, classified as a growth hormone secretagogue, appears to interact with the GHSRs, also known as ghrelin receptors, and may have the potential to impact bone growth