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Di(2-ethylhexyl) phthalate (DEHP), one of the most widely exposed plasticizers, has been shown to be closely associated with the development of breast cancer (BRCA) in epidemiological studies, but the specific mechanistic targets and related pathways are still unclear

Moderate stage , where there is notable cartilage loss in weight bearing regions, along with meniscal degeneration, evidence of osteophytes and subchondral sclerosis, and weakening of the quadriceps muscles