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The downregulated genes are primarily involved in fatty acid synthesis and energy metabolism, particularly enzymes critical to cell membrane composition and function

[DOI] [PMC free article] [PubMed] [Google Scholar] Oskoueian E., Abdullah N., Ahmad S., Saad W.Z., Omar A.R., Ho Y.W

The ceramide-1-phosphate (C1P), a phosphorylated derivative of ceramide, favors cell survival, proliferation, and anti-apoptotic signaling through the activation of PI3K/Akt, ERK1/2, and NF-B pathways

Nature 629 , 443449 (2024)

Different from previous predicting tools, this score-based risk model could act as a more efficient indicator for GC patients OS prediction and could help classification and individualized treatment for clinical application