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Many patients are unable to tolerate metformin for this reason

Front Immunol (2021) 12:696784

J Neuroinflammation 22:39 Yang Y et al (2025) Tumor-associated macrophages remodel the suppressive tumor immune microenvironment and targeted therapy for immunotherapy

Another immunomodulatory microbial metabolite is tryptophan-derived indoles, which activate the aryl hydrocarbon receptor (AhR) on astrocytes and intestinal immune cells [72]

Oxidative DNA damage is mainly caused by ROS, a complex process involving multiple reactions controlled by a combination of enthalpy, entropy, steric hindrance, and its constituent factors, as well as charge reactions and transport (7) ( Figure 1D )