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doi: 10.1212/NXI.0000000000001102 287 ZhangQSunWWangQZhengXZhangRZhangN

Mild to moderate nausea (peaking around days two to four), slight gastric discomfort, changes in bowel habits, fatigue, and occasional headaches are common first-week experiences

For example, hyperactive ribosome biogenesis can drive activation of oncogenes (e.g., En2 and n-Myc ) and silencing of tumor suppressor genes (e.g., Per2 and Diras2 ) in oxidatively damaged IVF embryos 48,49