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Scientific Communications: pathophysiology 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.01 - ACUTE MANAGEMENT - Neither thrombolysis nor thrombectomy O - ESOC25-1367 EFFECT OF CEREBROLYSIN ON CIRCULATING TIGHT JUNCTION PROTEINS AFTER REPERFUSION THERAPY Sawomir Michalak 1 , Jacek Namysl 2 , Krystyna Osztynowicz 3 , Joanna Rybacka-Mossakowska 2 1 Poznan University of Medical Sciences, Department of Neurochemistry and Neuropathology, Stroke Unit University Hospital Poznan, Poznan, Poland, 2 Poznan University of Medical Sciences, Stroke Unit University Hospital Poznan, Poznan, Poland, 3 Poznan University of Medical Sciences, Poznan, Poland Background and Aims: Experimental studies revealed that Cerebrolysin affects the integrity of the blood-brain barrier (BBB)

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The authors acknowledge financial support from the Wake Forest University Structural and Computational Biophysics training program [T32 GM095440 (predoctoral fellowship to JM)], Georgia Tech NIH T32 GM105490, Computational Biology and Predictive Health Training Grant (predoctoral fellowship to JL), Wake Forest Postdoctoral Program in Translational Radiation Oncology (T32 CA113267 to NODB), and PRIME-IRACDA postdoctoral fellowship (K12 GM102773 to EL)

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Unlike benzodiazepines, Selank has a low risk of tolerance and rebound anxiety