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Despite wide dose ranges tested (6 g/kg to 20 mg/kg), multiple administration routes (intramuscular, intraperitoneal, intravenous, oral), and varied dosing frequencies across numerous animal models, no acute lethal dose has been identified

Beyond serving as a diagnostic biomarker, elevated methylmalonic acid is believed to contribute to mitochondrial dysfunction and neuronal toxicity , linking metabolic imbalance to tissue-specific pathology

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Access this article Similar content being viewed by others Abbreviations MFPDS: Manchester Foot Pain and Disability Score MN: Mortons neuroma US: Ultrasound VAS: Visual analogue scale References Kasparek M, Schneider W (2013) Surgical treatment of Morton's neuroma: clinical results after open excision