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Description

The Bregs suppress CD8 + T cells, expand Tregs, and further promote M2 macrophage differentiation, collectively reinforcing tumor progression (175, 176)

Subsequently, the FairPark II, multi-center trial (NCT02655315, Table 2) was undertaken aiming to evaluate the effect of deferiprone on PD progression measured by the change of total MDS-UPDRS score between baseline and 36 weeks in 372 patients