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Furthermore, studies analyzing the autonomic manifestations of Long COVID have confirmed that the virus severely attenuates cardiac and vascular autonomic function, which directly impairs the secretomotor pathways responsible for tear production and pupillary control

[0289] The term "co-stimulatory ligand," as the term is used herein, includes a molecule on an antigen presenting cell {e.g., an APC, dendritic cell, B cell, and the like) that specifically binds a cognate co-stimulatory molecule on a T cell, thereby providing a signal which, in addition to the primary signal provided by, for instance, binding of a TCR/CD3 complex with an MHC molecule loaded with peptide, mediates a T cell response, including, but not limited to, proliferation, activation, differentiation, and the like

Hierarchical clustering were used to analyze the data

10.1038/s41467-024-51079-1 Nat Commun

Clin Cancer Res (2011) 17(24):7595604