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Also, the cytotoxicity of piperine was assessed by Sedeky et al., (2018) in which the results indicated that nanomicelles loaded with piperine exert toxicity on human brain tumor cells by inducing apoptosis and cell cycle arrest at G1 phase through reducing the expression of CDK2a, which is necessary for the progression of cell cycle

Endosomal sorting complex required for transport (ESCRT)-dependent exosome formation generates 30150 nm particles characterized by CD63, CD81, and tumor susceptibility gene 101 (TSG101) expression

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