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In Movie S1, for clarity, Thr-381 is shown only in conformation A

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While IL-6 secreted from adipose tissue is linked to chronic low-grade inflammation, exercise-induced IL-6 functions as a myokine with predominantly anti-inflammatory effects [184]

Otherwise, bile duct-ligated rats commonly presented intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension, gross brain swelling, hemorrhage and lesions, heart dysfunction, lung lesions, liver and kidney failure, gastrointestinal lesions, and severe arterial and venous thrombosis, peripherally and centrally

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