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With increasing hepatic dysfunction, the GH signaling cascade and hepatocyte IGF-I synthesis becomes impaired (124)

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Metabolic Pathway Analysis Researchers use IGF-1 LR3 to study interactions between growth-factor signaling and metabolic processes, including glucose uptake, lipid utilization, and energy production

This finding raises a hypothesis that this hydrophobic lock may be responsible for the basal activity of the receptor

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