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In particular, lysosomal cholesterol accumulation may predispose to APAP hepatotoxicity by a dual mechanism involving the impairment of mitophagy in hepatocytes and the disruption of TLR9 trafficking in LSEC

Ledo et al., 2016), in agreement with the existence of common pathological features between AD and major depressive disorder (Torrisi et al., 2019)

This modification affects chromatin structure and regulates gene expression

Excessive -synuclein aggregation in PD further exacerbates autophagy dysfunction while contributing to neuroinflammation

Chronic exposure to ethanol can lead to decreased serotonin levels due to its effects on the synthesis and release of serotonin, primarily by influencing tryptophan metabolism