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Understanding the difference is important because each concern responds differently to treatment

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Despite the uncertainty of the association, the relationship between melanoma and the RAS pathways is irrefutable, as not only do 50% of melanomas have BRAF mutations (particularly V600E) and 15% to 20% of these have NRAS mutations (particularly in codon 61) but also many melanomas have NF1 mutations, whether associated or not with the aforementioned mutations.47 The NF1 gene is therefore the third most affected gene in melanoma

Control Release 359 , 188205 (2023)